Document Type

Theses, Masters

Rights

This item is available under a Creative Commons License for non-commercial use only

Disciplines

Microbiology

Publication Details

Successfully submitted for the award of Master of Philosophy (M.Phil) to the Dublin Institute of Technology, 2004

Abstract

A series of transition metal complexes of 2-(4’-thiazolyl)benzimidazole{thiabendazole}(TBZH) have been prepared and their ability to prevent the growth of the fungal pathogen Candida albicans has been assessed. The compounds were synthesised using the Chloride, Nitrate, Sulfate and Acetate salts of MN(II), Fe(II), Fe(III), Co(II), Ni(II), Zn(II) and Ag(1) resulting in the formation of 29 metal complexes. The complexes were formulated on the basis of their physico-chemical data. Reaction of Fe(NO3)3.9H2) with TBZH yielded the unusual nitrate salt [TBZH2NO3], a compound which could not be generated using simple acid –base chemistry. The X-ray crystal structure of [TBZH2NO3] was determined. TBZH, [TBZH2NO3], the 29 complexes and the simple salt starting materials were all tested, over a range of concentrations, for their anti-Candida activity. At a concentration of 100ug/cm-3 all of the non-silver complexes exhibit good to moderate activity but as the concentration drops their efficacy diminishes significantly. The silver compounds examined during this study have excellent biological activity.

DOI

10.21427/D7ZT86

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