Document Type

Article

Rights

This item is available under a Creative Commons License for non-commercial use only

Disciplines

Biochemistry and molecular biology, Genetics and heredity

Publication Details

Frontiers in Genetics; Vol 5, No 311, 2014

Abstract

Althoughbestknownasariskfactorforcardiovasculardisease,cholesterolisavitalcomponentofallmammaliancells.Inadditiontokeystructuralroles,cholesterolisavitalbiochemicalprecursorfornumerousbiologicallyimportantcompoundsincludingoxysterolsandbileacids,aswellasactingasanactivatorofcriticalmorphogenicsystems(e.g.,theHedgehogsystem).Avarietyofsophisticatedregulatorymechanismsinteracttocoordinatetheoveralllevelofcholesterolincells,tissuesandtheentireorganism.Accumulatingevidenceindicatesthatinadditionaltothemore“traditional”regulatoryschemes,cholesterolhomeostasisisalsounderthecontrolofepigeneticmechanismssuchashistoneacetylationandDNAmethylation.Theavailableevidencesupportingaroleforthesemechanismsinthecontrolofcholesterolsynthesis,elimination,transportandstoragearethefocusofthisreview.

DOI

doi:10.3389/fgene.2014.00311

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