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1.6 BIOLOGICAL SCIENCES, Cell biology,, Biochemistry and molecular biology, Immunology, Neuroscience
In the United States, approximately 17,000 people per year are diagnosed with brain tumors, the leading cause of death from cancers in children ages 1-15 year (1,2). Gliomas are the most prevalent type of brain tumors in adults, affecting 3.2/100,000 persons/yr in the United States (www.CBTRUS.org). In spite of advances in surgery, chemotherapy, and radiotherapy, the mean survival time of patients post-diagnosis remains approximately 9-12 months.
Castro MG, Curtin JF, King GD, Candolfi M, Czer P, Sciascia SA, Kroeger K, Fakhouri T, Honig S, Kuoy W, Kang T, Johnson S and Lowenstein PR. Novel Gene Therapeutic Approaches to Brain Cancer. Gene Therapy for Neurological Disorders (Taylor & Francis Group) Chapter 13