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Submissions from 2010

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Release of HMGB1 in Response to Pro-Apoptotic Glioma Killing Strategies: Efficacy and Neurotoxicity, Marianela Candolfi, Kader Yagiz, David Foulad, Gabrielle Alzadeh, Matthew Tesarfreund, AKM Ghulam Muhammad, Mariana Puntel, Kurt Kroeger, Chunyan Liu, Sharon Lee, James Curtin, Gwendalyn D. King, Jonathan Lerner, Katsuaki Sato, Yohei Mineharu, Weidong Xiong, Pedro R. Lowenstein, and Maria Castro

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Comparative Study of Factor Xa Fluorogenic Substrates and Their Influence on the Quantification of LMWHs, Vanessa Castro-Lopez, Leanne F. Harris, James S. O'Donnell, and Anthony J. Killard

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Platelet Alpha- and Beta- Secretase Activities are not Significantly Affected by Dementia or Mild Cognitive Impairment in Swedish Patients., Paul Gorham, Natalie Bark, Ingemar Bjorkhem, Steve Meaney, and Milita Crisby

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Platelet alpha- and beta- secretase activities are not significantly affected by dementia or mild cognitive impairment in Swedish patients., Paul Gorham, Natalie Bark, Steve Meaney, Ingemar Bjorkhem, and Milita Crisby

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Development Of A Fluorescent Anti-Factor Xa Assay To Monitor Unfractionated And Low Molecular Weight Heparins, Leanne Harris, Vanessa Castro-Lopez, Nissrin Hammadi, James S. O'Donnell, and Tony Killard

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Self Protection from Anti-Viral Responses – Ro52 Promotes Degradation of the Transcription Factor IRF7 Downstream of the Viral Toll-Like Receptors, Rowan Higgs, Elisa Lazzari, Claire Wynne, Joan Ní Gabhann, Alexander Espinosa, Marie Wahren-Herlenius, and Caroline A. Jefferies

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Letter to the Editor, Charlotte Johnston Molloy, Clare Corish, John Kearney, Noirin Hayes, and Corina Glennon Slattery

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Differential Genome-Wide Array–Based Methylation Profiles in Prognostic Subsets of Chronic Lymphocytic Leukemia, Meena Kanduri, Nicola Cahill, Hanna Göransson, Camilla Enström, Fergus Ryan, Anders Isaksson, and Richard Rosenquist

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Food Consumption Trends and Drivers, John Kearney

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A Functional Polymorphism in the HMGCR Promoter Affects Transcriptional Activity but not the Risk for Alzheimer Disease in Swedish Populations., Lina Keller, Charlotte Murphy, and Steve Meaney

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High-density Screening Reveals a Different Spectrum of Genomic Aberrations in Chronic Lymphocytic Leukemia Patients with ‘Stereotyped’ IGHV3-21 and IGHV4-34 B-cell Receptors, Millaray Marincevic, Nicola Cahill, Rebeqa Gunnarsson, Anders Isaksson, Mahmoud Mansouri, Hanna Göransson, Markus Rasmussen, Mattias Jansson, Fergus Ryan, Karin Karlsson, Hans-Olov Adami, Fred Davi, Jesper Jurlander, Gunnar Juliusson, Kostas Stamatopoulos, and Richard Rosenquist

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An Evaluation of MIRU-VNTR Analysis and Spoligotyping for Genotyping of Mycobacterium Bovis Isolates and a Comparison with RFLP Typing., Joanne McLernon, Eamonn Costello, Orla Flynn, Gillian Madigan, and Fergus Ryan

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Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma, AKM Ghulam Muhammad, Mariana Puntel, Marianela Candolfi, A Salem, Kader Yagiz, C Farrokhi, Kurt Kroeger, Weidong Xiong, James Curtin, Chunyan Liu, K Lawrence, Niyati Bondale, Jonathan Lerner, G Baker, David Foulad, Robert Pechnick, Donna Palmer, Philip Ng, Pedro Lowenstein, and Maria Castro

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Factors Associated with Weaning Practices in Term Infants: a Prospective Observational Study in Ireland., Roslyn Tarrant, Katherine Younger, Margaret Sheridan-Pereira, Martin White, and John Kearney

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The Prevalence and Determinants of Breastfeeding Initiation and Duration in a Sample of Women in Ireland, Roslyn Tarrant, Katherine Younger, Margaret Sheridan-Pereira, Martin White, and John Kearney

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An Exploration of the Knowledge and Attitudes Towards Breastfeeding Among a Sample of Chinese Mothers in Ireland, Qianling Zhou, Katherine Younger, and John Kearney

Submissions from 2009

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HMGB1 Mediates Endogenous TLR2 Activation and Brain Tumor Regression, James Curtin, Naiyou Liu, Marianela Candolfi, Weidong Xiong, Hikmat Assi, Kader Yagiz, Matthew Edwards, Kathrin Michelsen, Kurt Kroeger, Chunyan Liu, AKM Ghulam Muhammad, Mary Clark, Moshe Arditi, Begonya Comin-Anduix, Antoni Ribas, Pedro Lowenstein, and Maria Castro

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High-Density Screening Reveals a Different Spectrum of Genomic Aberrations in Chronic Lymphocytic Leukemia Patients with "stereotyped" IGHV3-21 and IGHV4-34 B-Cell Receptors, Millaray Marincevic, Nicola Cahill, Rebeqa Gunnarsson, Anders Isaksson, Mahmoud Mansouri, Mattias Jansson, Fergus Ryan, Karin Karlsson, Hans-Olov Adami, Fred Davi, Jesper Jurlander, Gunnar Juliousson, Kostas Stamatopoulos, and Richard Rosenquist

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An Evaluation of MIRU-VNTR Analysis and Spoligotyping for Genotyping of M. Bovis Isolates and a Comparison with RFLP Typing, Joanne McLernon, Eamon Costello, Orla Flynn, Gillian Madigan, and Fergus Ryan

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Transcriptional Regulation of Cholesterol 24-hydroxylase by Histone Deacetylase Inhibitors., Marjan Shafaati, Riona O'Driscoll, Ingemar Bjorkhem, and Steve Meaney

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Adenovirus E4orf4 Induces HPV-16 Late L1 mRNA Production, Monica Somberg, Margaret Rush, Joanna Fay, Fergus Ryan, Helen Lambkin, Göran Akusjärvi, and Stefan Schwartz

Submissions from 2008

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Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials., James Curtin, Marianela Candolfi, Tamer Fakhouri, Chunyan Liu, Anderson Alden, Matthew Edwards, Pedro Lowenstein, and Maria Castro

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Regulated Expression of Adenoviral Vectors-Based Gene Therapies: Therapeutic Expression of Toxins and Immune-Modulators, James Curtin, Marianela Candolfi, Mariana Puntel, Weidong Xiong, AKM Ghulam Muhammad, Kurt Kroeger, Sonali Mondkar, Chunyan Liu, Niyati Bondale, Pedro Lowenstein, and Maria Castro

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Turning the Gene Tap off; Implications of Regulating Gene Expression for Cancer Therapeutics, James Curtin, Marianela Candolfi, Weidong Xiong, Pedro Lowenstein, and Maria Castro

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Laboratory Diagnosis of Clostridium Difficile in the Republic of Ireland: a Survey of Irish Microbiology Laboratories., Denise Drudy, F. Fitzpatrick, A. Oza, A. Gilleece, and A. M. O’Byrne

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Clindamycin Resistant clone of C. difficile PCR ribotype 027 in Europe, Denise Drudy, B. Goorhuis, Dennis Bakker, Lorraine Kyne, Renate Van der Berg, Lynda Fenelon, and Seamus Fanning

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Update of Clostridium Difficile Infection Due to PCR Ribotype 027 in Europe, 2008, Denise Drudy, E. J. Kuijper, F. Barbut, and J. S. Brazier

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The Development of a Qualitative Real-Time RT-PCR Assay for the Detection of Hepatitis C Virus, Celine Herra, A. Clancy, B. Crowley, and H. Niesters

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Evaluation of the Xpert Methicillin-Resistant Staphylococcus Aureus (MRSA) Assay Using the GeneXpert Real-Time PCR Platform for Rapid Detection of MRSA From Screening Specimens., Celine M. Herra Dr

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Detection of Staphylococcal Cassette Chromosome mec Associated DNA Segments in Multiresistant MSSA and Identification of Staphylococcus epidermidis ccrAB4, Celine Herra; Anna Shore; Brian O’Connell,; Angela Rossney,; Derek Sullivan; Hilary Humphreys; and David Coleman

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Novel functions of acyl-CoA thioesterases and acyltransferases as auxiliary enzymes in peroxisomal lipid metabolism., Mary Hunt and Stefan Alexson

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Book Review J. Mann & A. S. Truswell (editors). Essentials of Human Nutrition., Daniel McCartney

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The Nudix Hydrolase 7 is an Acyl-CoA Diphosphatase Involved in Regulating Peroxisomal Coenzyme A homeostasis., Sarah-Jayne Reilly, Veronica Tillander, Rob Ofman, Stefan Alexson, and Mary Hunt

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Session 1: Public health nutrition Breast-feeding practices in Ireland, Roslyn Tarrant and John Kearney

Submissions from 2007

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Mutagenesis of the Catalytic Triad of Tissue Transglutaminase, Greg Byrne, Fergus Ryan, John Jackson, Con Feighery, and Jacinta Kelly

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Mutagenesis of the Catalytic Triad of Tissue Transglutaminase Abrogates Coeliac Disease Serum IgA Autoantibody Binding, Greg Byrne, Fergus Ryan, John Jackson, Con Feighery, and Jacinta Kelly

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Adenoviral Mediated Gene Transfer into the Dog Brain In Vivo, Marianela Candolfi, Kurt Kroeger, Elizabeth Pluhar, Chunyan Liu, Carlos Barcia, Josee Bergeron, Mariana Puntel, James Curtin, Elizabeth McNiel, Andrew Freese, John Ohlfest, Peter Moore, William Kuoy, Pedro Lowenstein, and Maria Castro

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The acyl-CoA thioesterase I (Acot1) is regulated by the peroxisome proliferator-activated receptor alpha and hepatocyte nuclear factor 4 alpha via a distal response element in the promotor., Bikesh Dongol, Yatrik Shah, Insook Kim, Frank J. Gonzalez, and Mary Hunt

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Emergence and control of Fluoroquinolone Resistant Toxin A Negative Toxin B positive Clostridium difficile, Denise Drudy, N. Harnedy, S. Fanning, and L. Kyne

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GyrA mutations in Fluoroquinolone Resistant Clostridium difficile PCR 027, Denise Drudy, Lorraine Kyne, Rebecca O’Mahony, and Séamus Fanning

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Evaluation of the IDI-MRSA assay on the SmartCycler real-time PCR platform for rapid detection of MRSA from screening specimens, Celine Herra, A. S. Rossney, M. Fitzgibbon, P. Morgan, and B. O’Connell

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Alternative Exon Usage Selectively Determines Both Tissue Distribution and Subcellular Localization of the acyl-CoA Thioesterase 7 Gene Products., Mary Hunt, Sinead Greene, Kjell Hultenby, L. Thomas Svensson, Susanna Engberg, and Stefan E H Alexson

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Human Papillomavirus Prevalence and Genotypes in an Opportunistically Screened Irish Female Population, Helen Keegan, Fergus Ryan, Alison Malkin, Mairead Griffin, and Helen Lambkin

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Chlamydia Trachomatis Detection in Cervical PreservCyt Specimens From an Irish Urban Female Population, Helen Keegan, Fergus Ryan, Alison Malkin, M. Griffin, and Helen Lambkin

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Hepatitis B Virus Resistance to Adefovir in a Nucleotide Naive Patient with Chronic Hepatitis B Virus Infection, B Laoi, Celine M. Herra Dr, S. Norris, and B. Crowley

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PPARα is a Key regulator of Hepatic FGF21, Thomas Lundasen, Mary Hunt, Lisa-Marie Nilsson, Sabysashi Sanyal, Bo Angelin, Stefan Alexson, and Mats Rudling

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A Peroxisomal Acyltransferase in Mouse Identifies a Novel Pathway for Taurine Conjugation of Fatty Acids., Sarah-Jayne Reilly, Eithne O'Shea, O'Byrne James, Stefan Alexson, and Mary Hunt

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Peroxisomes Contain a Specific Phytanoly-CoA/Pristanoyl-CoA Thioesterase Acting as a Novel Auxiliary Enzyme in Alpha-and Beta-Oxidation of Methyl-Branched Fatty Acids in Mouse, Maria Westin, Mary Hunt, and Stefan Alexson

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Identification of a 17-Nucleotide Splicing Enhancer in HPV-16 L1 that Counteracts the Effect of Multiple hnRNP A1-binding Splicing Silencers, Ziaomin Zhao, Joanna Fay, Stefan Schwartz, and Helen Lambkin

Submissions from 2006

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In Vivo Mature Immunological Synapses Forming SMACs Mediate Clearance of Virally Infected Astrocytes From the Brain, Carlos Barcia, Clare Thomas, James Curtin, Gwendalyn King, Kolja Wawrowsky, Marianela Candolfi, Weidong Xiong, Chunyan Liu, Kurt Kroeger, Olivier Boyer, Jerzy Kupiec-Weglinski, David Klatzmann, Maria Castro, and Pedro Lowenstein

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Fms-Like Tyrosine Kinase 3 Ligand Recruits Plasmacytoid Dendritic Cells to the Brain, James Curtin, Gwendalyn King, Carlos Barcia, Chunyan Liu, Francois Hubert, Carole Guillonneau, Regis Josien, Ignacio Anegon, Pedro Lowenstein, and Maria Castro

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Comparative phylogenomics of Clostridium difficile reveals clade specificity and microevolution of hypervirulent strains., Denise Drudy

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Isolation and Characterization of toxin A-negative, toxin B-positive Clostridium difficile in Dublin, Ireland, Denise Drudy, N. Harnedy, S. Fanning, R. O’Mahony, and L. Kyne

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Characterization of a Collection of Enterobacter sakazakii isolates from Environmental and Food Sources., Denise Drudy, Michele O'Rourke, Mary Murphy, Niall Mullane, Rebecca O'Mahony, Lorainne Kelly, Matthias Fischer, Suhad Sanjag, Pauline Shannon, Patrick Wall, Micheál O'Mahony, Paul Whyte, and Séamus Fanning

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High-level Resistance to Moxifloxacin and Gatifloxacin Associated with a Novel Mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile, Denise Drudy, T. Quinn, R. O'Mahony, L. Kyne, P. O'Gaora, and S. Fanning

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Analysis of Enzyme, Carbohydrate and Mineral Distribution In the Foot of Abalone Shellfish., Leanne F. Harris, Nuala O'Byrne-Ring, and Helen Lambkin

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Characterisation Of Cell Types In Abalone (Haliotis spp.) Tissues Using Immunohistochemical Techniques, Leanne Harris, Nuala O'Byrne-Ring, and Helen Lambkin

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Analysis of the Mouse and Human acyl-CoA Thioesterase (ACOT) Gene Clusters Shows That Convergent, Functional Evolution Results in a Reduced Number of Human Peroxisomal ACOTs., Mary Hunt, Anna Rautanen, Maria Westin, Thomas Svensson, and Stefan Alexson

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First Report of Genotypic Resistance to Adefovir in Chronic HBV in the Republic of Ireland, B. Laoi, Celine Herra, S. Norris, and B. Crowley

Submissions from 2005

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Endostatin Modulates VEGF-Mediated Barrier Dysfunction in the Retinal Microvascular Endothelium, Brenda Brankin, M. Campbell, P. Canning, T. Gardiner, and A. Stitt

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Development and Validation of a Food-Frequency Questionnaire for the Determination of Detailed Fatty Acid Intakes, Maria Cantwell, Michael Gibney, Denis Cronin, Katherine Younger, John O'Neill, Linda Hogan, and Mary Flynn

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Combining Cytotoxic and Immune-Mediated Gene Therapy to Treat Brain Tumors, James Curtin, Gwendalyn King, Marianela Candolfi, Remy Greeno, Kurt Kroeger, Pedro Lowenstein, and Maria Castro

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Gene Therapy and Targeted Toxins for Glioma, James Curtin, Gwendalyn King, Marianela Candolfi, Kurt Kroeger, Pedro Lowenstein, and Maria Castro

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Regulatable Gene Expression Systems for Gene Therapy Applications: Progress and Future Challenges, Shyam Goverdhana, Mariana Puntel, Weidong Xiong, Jeffrey Zirger, Carlos Barcia, James Curtin, Eric Soffer, Sonali Mondkar, Gwendalyn King, Jinwei Hu, Marianela Candolfi, Diane Greengold, Pedro Lowenstein, and Maria Castro

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New insights into bile acid amidation, Mary Hunt, Eithne O'Shea, Karianne Solaas, Bengt Kase, and Stefan Alexson

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Identification of fatty acid oxidation disorder patients with lowered acyl-CoA thioesterase activity in human skin fibroblasts, Mary Hunt, Jos Ruiter, Petra Mooyer, Carlo W T van Roermond, Rob Ofman, Lodewig Ijlst, and Ronald J A Wanders

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A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases, Mary Hunt, Junji Yamada, Lois Maltais, Mathew Wright, Ernesto Podesta, and Stefan Alexson

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Comparison of DNA Extraction from Cervical Cells Collected in PreservCyt Solution for the Amplification of Chlamydia Trachomatis, Helen Keegan, Clara Boland, Alison Malkin, Mairead Griffin, Fergus Ryan, and Helen Lambkin

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Validation of a Multiplex PCR Assay for the Simultaneous Detection of Human Papillomavirus and Chlamydia Trachomatis in Cervical PreservCyt Samples., Helen Keegan, Alison Malkin, Mairead Griffin, Fergus Ryan, and Helen Lambkin

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Real-time Reverse Transcription PCR for Detection and Quantitative Analysis of Equine Influenza Virus., Michelle Quinlivan, Eugene Dempsey, Fergus Ryan, Sean Arkins, and Ann Cullinnane

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Real-Time Reverse Transcription PCR for Detection and Quantitative Analysis of Equine Influenza Virus, Michelle Quinlivan, Eugene Dempsey, Fergus Ryan, Sean Atkins, and Ann Cullinane

Submissions from 2004

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JNK Regulates HIPK3 Expression and Promotes Resistance to Fas-mediated Apoptosis in DU 145 Prostate Carcinoma Cells, James Curtin and Thomas Cotter

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Detection of Five Common CFTR Mutations by Rapid-Cycle Real Time Amplification Refractory Mutation System PCR., Eugene Dempsey, David Barton, and Fergus Ryan

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Assessment of Obesity and Fear of Fatness Among Inner-City Dublin Schoolchildren in a One-Year-Follow-Up Study, Anne Griffin, Katherine Younger, and Mary Flynn

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Increased Frequency of the MTHFR A1298C Mutation in an Irish Population, Cathal McCarthy, Fergus Ryan, and Joseph Vaughan

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Increased frequency of the MTHFR A1298C mutation in an Irish population., Fergus Ryan, Cathal McCarthy, and Joseph Vaughan

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Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARa) regulated peroxisomal acyl-CoA thioesterases., Maria Westin, Mary Hunt, and Stefan Alexson

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Isolation of cancer stem cells from adult glioblastoma multiforme, Xianpeng Yuan, James Curtin, Yizhi Xiong, Gentao Liu, Sebastian Waschsmann-Hogiu, Daniel Farkas, Keith Black, and John Yu

Submissions from 2003

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Defects in death-inducing signalling complex formation prevent JNK activation and Fas-mediated apoptosis in DU 145 prostate carcinoma cells, James Curtin and Thomas Cotter

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Historical perspectives (Apoptosis), James Curtin and Thomas Cotter

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Live and let die: regulatory mechanisms in Fas-mediated apoptosis, James Curtin and Thomas Cotter

Submissions from 2002

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Anisomycin activates JNK and sensitises DU 145 prostate carcinoma cells to Fas mediated apoptosis, James Curtin and Thomas Cotter

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Regulation and measurement of oxidative stress in apoptosis, James Curtin, Maryanne Donovan, and Thomas Cotter

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Characterization of an Acyl-Coa Thioesterase that Functions as a Major Regulator of Peroxisomal Lipid Metabolism, Mary Hunt, Karianne Solaas, Bengt F. Kase, and Stefan E H Alexson

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Intrafamilial Phenotypic Variability in Friedreich Ataxia Associated With a G130V Mutation in the FRDA Gene, Dominick McCabe, Nicholas Wood, Fergus Ryan, Michael Hanna, Sean Connolly, David Moore, Janice Redmond, David Barton, and Raymond Murphy

Submissions from 2001

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Attitudes Towards and Beliefs about Nutrition and Health Among a Random Sample of Adults in the Republic of Ireland and Northern Ireland, John Kearney, Michael Gibney, Barbara Livingstone, Paula Robson, Mairead Kiely, and Karen Harrington

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Attitudes Towards and Beliefs about Nutrition and Health Among a Random Sample of Adults in the Republic of Ireland and Northern Ireland, John Kearney, Michael Gibney, Barbara Livinstone, Paula Robson, Mairead Kiely, and Karen Harrington

Submissions from 2000

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The Peroxisome Proliferator-Activated Receptor Alpha (PPAR ) regulates Bile Acid Biosynthesis., Mary Hunt, Yi-Zeng Yang, Gosta Eggertsen, Claes Carneheim, Mats Gafvels, Curt Einarsson, and Stefan Alexson

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Typical Friedreich’s Ataxia without GAA Expansions and GAA Epansions Wthout Typical Friedreich’s Ataxia, Dominick McCabe, Fergus Ryan, D. Moore, Shirley McQuaid, M. King, A. Kelly, K. Daly, David Barton, and R. Murphy

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Haemochromatosis mutation analysis in a normal Irish population, Fergus Ryan and Joseph Vaughan

Submissions from 1999

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Hyperinsulinism Caused by Paternal-Specific Inheritance of a Recessive Mutation in the Sulfonylurea-Receptor Gene, Benjamin Glaser, Fergus Ryan, Marc Donath, Heddy Landau, Charles Stanley, Lester Baker, David Barton, and Paul Thornton

Submissions from 1998

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Title, Fergus Ryan, D Devaney, Caroline Joyce, A Nestorowicz, M Permutt, Benjamin Glaser, Paul Thornton, and David E. Barton

Submissions from 1981

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The Effect of Dietary Supplements of w3 Polyunsaturated Fatty Acids on the Fatty Acid Composition of Platelets and Plasma Choline Phosphoglycerides, T. Sanders and Katherine Younger