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Biochemistry and molecular biology
Acyl-CoA thioesterases, also known as acyl-CoA hydrolases, are a group of enzymes that hydrolyze CoA esters such as acyl-CoAs (saturated, unsaturated, branched chain), bile acid-CoAs, CoA esters of prostaglandins etc, to the corresponding free acid and coenzyme A. There is however significant confusion regarding the nomenclature of these genes. In agreement with the HUGO Gene Nomenclature Committee (HGNC) and the Mouse Genomic Nomenclature Committee (MGNC), a revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases has been suggested for the 12 member family. The family root symbol is ACOT, with human genes named ACOT1-12, and rat and mouse named Acot1-12. Several of the ACOT genes are the result of splicing events and these splice variants are catalogued.
Hunt, M., Maltais, L., Wright, M., Podesta, E., Alexson, S.:A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. Journal of Lipid Research, Vol. 45:(10), 2004,pp. 1958-1961. doi:10.1194/jlr.E400002-JLR200