This item is available under a Creative Commons License for non-commercial use only
BACKGROUND: Asthma is a common childhood respiratory disease, affecting around 20% of Irish children. In other populations, vitamin D receptor (VDR) polymorphisms have been associated with asthma risk. We aimed to investigate the association between 2 VDR polymorphisms and uncontrolled paediatric asthma. METHODS: 44 asthmatic children and 57 healthy volunteers were studied. The VDR TaqI gene variant in exon 9 (T/C) (rs731236) and ApaI (rs7975232) in intron 8 (C/T) were determined, using TaqMan®Assays. The lung function, serum 25-hydroxyvitamin D (25OHD) levels and other biomarkers of allergy, immunity, airway and systemic inflammation were assessed. RESULTS: The distribution of T and C alleles and genotype frequencies differed significantly between asthmatics and controls for both polymorphisms (p
Hutchinson K, Kerley CP, Faul J, Greally P, Coghlan D, Louw M, Elnazir B, Rochev Y. (2017) European Annals of Allergy and Clinical Immunology, 2017, Nov. 28th. [Epub ahead of print]. doi: 10.23822/EurAnnACI.1764-1489.46.