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1.6 BIOLOGICAL SCIENCES
Since the emergence of a new virulent strain of Clostridium difficile characterised as toxinotype III, North American pulsedfield type 1 (NAP1), restriction-endonuclease analysis group type BI and PCR-ribotype 027 (Type 027), multiple outbreaks have been reported in North America and Europe [1-9]. The increased virulence of C. difficile Type 027 is thought to be associated with a 1 base pair deletion at position 117 of the tcdC gene which leads to an increased or prolonged production of toxins A and B, and possibly the production of a binary toxin [1-3]. However, these virulence factors are not unique for Type 027 and are also present in other PCR ribotypes.
Drudy, D. et al (2008) Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008. Eurosurveillance. 13 (31),p.18942. doi:10.21427/D7KS6P