Document Type

Article

Rights

This item is available under a Creative Commons License for non-commercial use only

Disciplines

Particles and fields physics

Publication Details

Toxicology and Applied Pharmacology, Nov 1, vol.248 (3), 2010,pp.259-68. Epub Aug 22, 2010.

Abstract

Poly(amidoamine) (PAMAM) dendrimer nanoparticles have been demonstrated to elicit a well defined cytotoxicological response from mammalian cell lines, the response increasing systematically with dendrimer generation and number of surface amino groups. In this work, using generation G4, G5, and G6 dendrimers, this systematic response is furthermore demonstrated for the generation of reactive oxygen species, lysosomal activity, and the onset of apoptosis and levels of DNA damage. The results are consistent with a pathway of localisation of PAMAM dendrimers in the mitochondria leading to ROS production causing oxidative stress, apoptosis and DNA damage. ROS production is co-located in the mitochondria, and both generated levels and timescales are systematically generation dependent (G4

DOI

10.1016/j.taap.2010.08.016

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