Document Type

Article

Rights

This item is available under a Creative Commons License for non-commercial use only

Disciplines

Inorganic and nuclear chemistry

Publication Details

Medicinal Chemistry Communications 2011, 2, pp.579-584

DOI: 10.1039/C0MD00266F

Abstract

Dinuclear CuII and MnII bis-phenanthroline octanedioate complexes exhibit rapid, unprecedented nano and picomolar in vitro cytotoxicity against colorectal cancer lines and are less toxic than cisplatin when examined in vivo. The complexes are potent generators of cellular reactive oxygen species, avid DNA binders and induce O2 dependent cleavage of DNA. The Cu(II) complex was found to have self-cleaving nuclease activity.

DOI

10.1039/c0md00266f

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Chemistry Commons

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