Document Type

Article

Rights

This item is available under a Creative Commons License for non-commercial use only

Disciplines

Physical chemistry

Publication Details

Journal of Inclusion Phenomena and Macrocyclic Chemistry, Volume 69, Numbers 3-4, April 2011 , pp. 321-325(5)

Abstract

A novel folic acid–b-cyclodextrin (b-CD) conjugate was synthesized and preliminarily characterized by 1H NMR, ESI-MS, and MALDI-MS. 1H NMR shows the presence of a- and c-conjugates which are generated by b-CD linkage in turn with both carboxylic functions of folic acid. Moreover ROESY evidences supramolecular interactions between the benzene ring of the folic acid and the b-CD cavity. DOSY suggests that ethylenediamine derived b-CD–folic acid forms a colloidal dispersion difficult to purify from free folic acid. An analysis of self-diffusion coefficient (Ds) of the three species (a-, c-conjugates, and free folic acid) and relaxation times (T1 and T2) is reported to tentatively explain the colloidal behaviour of the new species in an aqueous solution.

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