Copper(II) Complexes of Coumarin-Derived Schiff Bases and their anti-Candida Activity

Authors

Bernadette S. Creaven, Technological University DublinFollow
Michael Devereux, Technological University DublinFollow
Dariusz Karcz, Technological University DublinFollow
Andrew Kellett, Technological UniversityFollow
Malachy McCann, National University of Ireland, Maynooth
Andy Noble, University of Otago
Maureen Walsh, Technological University DublinFollow

Document Type

Article

Rights

Available under a Creative Commons Attribution Non-Commercial Share Alike 4.0 International Licence

Disciplines

Inorganic and nuclear chemistry

Publication Details

Journal of Inorganic Biochemistry, 103 (2009) 1196–1203

Abstract

The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a–2k) in good yields. Subsequent reaction of these ligands with copper( II) acetate yielded Cu(II) complexes (3a–3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity.

Recommended Citation

Creaven, B. et al. Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity. Journal of Inorganic Biochemistry, 103 (2009) 1196–1203. doi:10.1016/j.jinorgbio.2009.05.017

Funder

Technological Sector Research Programme, Strand 1, under the European Social Fund