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Computer Sciences, Biology, Cardiac and Cardiovascular systems
Coronary stent implantation can improve blood flow in an artery that has been narrowed by the build up of arterial plaque. However, the haemodynamic effect of stent placement is unclear and may influence arterial restenosis (re-blockage). The degree of tissue prolapse between stent struts may be an important factor in predicting the restenosis rate of a stent due to the haemodynamic influence of the protruding tissue. In this paper a mathematical model has been developed to numerically predict the tissue prolapse for an artery implanted with a coronary stent. The prolapse model has been applied to the Gianturco-Roubin II (GR-II) coil stent (Cook, USA) and the Palmaz-Schatz (PS) slotted tube stent (Johnson & Johnson, USA). Finally, computational fluid dynamics (CFD) is used to predict the blood flow through both stented arteries with the tissue protrusion as predicted by the prolapse model.
Murphy, J., Boyle, F.: Development of a Three Dimensional Prolapse Model to Simulate Physiological Haemodynamics in a Stented Coronary Artery. Sixth IASTED International Conference on Biomedical Engineering. 2008.