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Biochemistry and molecular biology, Medical engineering
A crosslinked, multicomponent scaffold of collagen, GAG and fibrin has been characterised for heart valve applications. Fibrin gels reinforced with a 0.75% collagen, 0.044% GAG scaffolds can resist VSMC induced contraction significantly more than fibrin-only gels, while allowing cell proliferation and maintaining excellent cell viability. This improvement in structural integrity may facilitate the use of fibrin based materials for heart valve tissue engineering.
Brougham, C., Cooney, G., Jockenhoevel , S., Flanagan, T.C., O'Brien, F.J. : A New Reinforced Fibrin Collagen Glycosaminoglycan Material to Resist Tissue Contraction in Heart Valves, 7th World Congress in Biomechanics, Boston, MA, 2014.