Macular Pigment and its Correlation with Colour Vision and SWAP Perimetry
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3. MEDICAL AND HEALTH SCIENCES, Ophthalmology
Purpose To investigate the effects of macular pigment optical density (MPOD) on colour vision and colour modulated visual fields using short-wavelength automated perimetry (SWAP). Methods Macular pigment (MP) spatial profile was measured using customised heterochromatic flicker photometry (cHFP) on 51 normal subjects. Colour vision was assessed using the Oculus anomaloscope [Moreland equation (AME)] and Farnsworth-Munsell 100-Hue (FM) with optimum confusion axes. A custom designed program on the Humphrey automated perimeter, was used to determine SWAP thresholds at the fovea, and at each degree of retinal eccentricity for the central five degrees. A 440nm Goldmann V stimulus presented on a 100cd/m2 bleaching background was used to isolate the short wave sensitive pathway. Results While inter-relationships were evident between AME, FM and SWAP, only one colour vision measure (on FM) correlated with MPOD (r=.302, p= 0.03). At similar degrees of eccentricity, SWAP was inversely and statistically significantly correlated with MPOD (e.g. 1-degree retinal eccentricity: r = -0.198, p = 0.047; 3 degrees retinal eccentricity r = -0.290, p = 0.03). Conclusion Colour vision, even using sensitive tests targeting blue-yellow and blue-green confusion is surprisingly independent of MPOD, while SWAP sensitivity is reduced with increased MPOD. We hypothesize that this is due to long-term adaptation of the retinal blue-yellow pathway to prevailing MPOD in normal subjects, this adaptation being upset by short-term chromatic adaptation in SWAP.
Loughman, J., Davison, P., Scanlon, G.: Macular pigment and its correlation with colour vision and SWAP perimetry. European Vision and Eye Research conference, Acta Ophthalmologica. 2008.
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