Photochemical Studies of Nutraceuticals in the Presence of Cyclodextrins
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Physical chemistry, Pharmacology and pharmacy, Nutrition, Dietetics
The photostability studies of Folic acid and Menadione Sodium Bisulfite, also known as vitamin K3, were carried out in their aqueous solutions at room temperature. Solutions of Folic acid ( 4.8 x 10-5 M) and Menadione Sodium Bisulfite (4.0 x 10-4 M) were exposed to ultraviolet radiation at a wavelength of 365 nm. During exposure absorbance of both solutions was measured using a Perkin Elmer Lamda 900 UV/VIS/NIR Spectrometer. During the stability tests it was noted that addition of β Cyclodextrin (1:1 ratio) to aqueous solutions containing the vitamin slowed down the photodegradation process. The unique shape of Cyclodextrins allows whole or partial inclusion of nutrients inside their cavity. The obtained results suggests that the physical mixture of β-Cyclodextrin with Folic acid or vitamin K3 enhances the photostability of the nutrients
Tofzikovskaya, Z., O’Connor, C., McNamara, M.: Photochemical studies of Nutraceuticals in the presence of Cyclodextrins. 14th International Cyclodextrins Symposium, Kyoto, Japan, May, 2008.