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Organic Chemistry, Medicinal chemistry
Artemisinin–acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2–4-fold increase in activity against HL60, MDA-MB-231 and MCF-7 cells in comparison with dihydroartemisinin (DHA) and moderate antimalarial activity. Strong evidence that the compounds induce apoptosis in HL60 cells was obtained by flow cytometry, which indicated accumulation of cells in the G1 phase of the cell cycle.
Jones, Michael Dr; Mercer, Amy E. Dr; Stocks, Paul A. Dr; La Pensee, Louise L.J. Dr; Cosstick, Rick Dr; Park, B. Kevin Prof; Kennedy, Miriam E.; Piantanida, Ivo Prof; Ward, Stephen A. Prof; Davies, Jill; Bray, Patrick G. Dr; Rawe, Sarah; Baird, Jonathon; Charidza, Tafadzwa Dr; Janneh, Omar Dr; and O'Neill, Paul M. Prof, "Antitumour and antimalarial activity of artemisinin–acridine hybrids" (2009). Articles. Paper 17.