Document Type
Article
Rights
This item is available under a Creative Commons License for non-commercial use only
Disciplines
Organic Chemistry, Medicinal chemistry
Abstract
Artemisinin–acridine hybrids were prepared and evaluated for their in vitro activity against tumour cell lines and a chloroquine sensitive strain of Plasmodium falciparum. They showed a 2–4-fold increase in activity against HL60, MDA-MB-231 and MCF-7 cells in comparison with dihydroartemisinin (DHA) and moderate antimalarial activity. Strong evidence that the compounds induce apoptosis in HL60 cells was obtained by flow cytometry, which indicated accumulation of cells in the G1 phase of the cell cycle.
Recommended Citation
Jones, Michael Dr; Mercer, Amy E. Dr; Stocks, Paul A. Dr; La Pensee, Louise L.J. Dr; Cosstick, Rick Dr; Park, B. Kevin Prof; Kennedy, Miriam E.; Piantanida, Ivo Prof; Ward, Stephen A. Prof; Davies, Jill; Bray, Patrick G. Dr; Rawe, Sarah; Baird, Jonathon; Charidza, Tafadzwa Dr; Janneh, Omar Dr; and O'Neill, Paul M. Prof, "Antitumour and antimalarial activity of artemisinin–acridine hybrids" (2009). Articles. Paper 17.
http://arrow.dit.ie/scschcpsart/17
Included in
Heterocyclic Compounds Commons, Parasitic Diseases Commons, Pharmaceutics and Drug Design Commons
Publication Details
Bioorganic and Medicinal Chemistry Letters