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A novel folic acid–b-cyclodextrin (b-CD) conjugate was synthesized and preliminarily characterized by 1H NMR, ESI-MS, and MALDI-MS. 1H NMR shows the presence of a- and c-conjugates which are generated by b-CD linkage in turn with both carboxylic functions of folic acid. Moreover ROESY evidences supramolecular interactions between the benzene ring of the folic acid and the b-CD cavity. DOSY suggests that ethylenediamine derived b-CD–folic acid forms a colloidal dispersion difficult to purify from free folic acid. An analysis of self-diffusion coefficient (Ds) of the three species (a-, c-conjugates, and free folic acid) and relaxation times (T1 and T2) is reported to tentatively explain the colloidal behaviour of the new species in an aqueous solution.
Clementi, A., Aversa, M., Corsaro, C., Spooren, J., Stancanelli, R., O'Connor, C., McNamara, M., Mazzaglia, A.: Synthesis and Characterization of a Colloidal Novel Folic Acid–β-cyclodextrin Conjugate for Targeted Drug Delivery. Journal of Inclusion Phenomena and Macrocyclic Chemistry, Volume 69, Numbers 3-4, pp. 321-325(5). April, 2011.