This item is available under a Creative Commons License for non-commercial use only
Inorganic and nuclear chemistry
Dinuclear CuII and MnII bis-phenanthroline octanedioate complexes exhibit rapid, unprecedented nano and picomolar in vitro cytotoxicity against colorectal cancer lines and are less toxic than cisplatin when examined in vivo. The complexes are potent generators of cellular reactive oxygen species, avid DNA binders and induce O2 dependent cleavage of DNA. The Cu(II) complex was found to have self-cleaving nuclease activity.
Kellett, Andrew; O'Connor, Mark; McCann, Malachy; Howe, Orla; Casey, Alan; McCarron, Pauric; Kavanagh, Kevin; McNamara, Mary; Kennedy, Sean; May, Donald D.; Skell, Philip S.; O'Shea, Denis; and Devereux, Michael, "Water-soluble CuII and MnII bis-phenanthroline octanedioate complexes with unprecedented nano and picomolar in vitro cytotoxicity as promising leads for chemotherapeutic drug development" (2011). Articles. Paper 12.