Document Type

Article

Rights

This item is available under a Creative Commons License for non-commercial use only

Disciplines

Cell biology,, Microbiology

Publication Details

Centre of Microbial Host Interactions and Centre of Applied Science for Health, Institute of Technology Tallaght, Tallaght, Dublin 24, Ireland.

Current opinion in microbiology. 12/2011; 15(1):71-7. DOI:10.1016/j.mib.2011.11.00

Abstract

Chronic infection is a hallmark of cystic fibrosis (CF) and the main contributor to morbidity. Microbial infection in CF is complex, due to the number of different species that colonise the CF lung. Their colonisation is facilitated by a host response that is impaired or compromised by highly viscous mucous, zones of hypoxia and the lack of the cystic fibrosis transmembrane regulator (CFTR). Successful dominant CF pathogens combine an effective arsenal to establish infection and counter-attack the host response, together with an ability to adapt readily to an unfavourable environment. Hypermutability is common among CF pathogens facilitating adaptation and as the host response persists, progressive destruction of the normal architecture of lung tissue ensues with catastrophic consequences for the host.